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M?NO???? x?$f烃?(& ? ?(?$?$? ???? ? ???? ???? ???$???? ???? ?  ? ???? ???? ? ? ???? ???? $? ??? ? ???? ???? ???? ???? ???? #? ???B   ?  ??? ?b6R?QR?? ????@?????uBR?? ?" ??WSOT???? }0?R?S } ?" ??WSOMR??ACTH0TSH0?'`z?? } ?" vQ?[???\ }0???n? ? ?b6R?a^y??>eNAh}? ?(?( ?????$??????? ? ???????????? ??????? ? ???? ?(??? ?(,8 !? OG??Ca2+??bo??v\O(u?_T &?0.?0&?0??0 ??& ???S??HT N??` & 5u?S?OV?'` 5u?S??'`Ca2+?S??v?R??To?ir?KN\O(u;N???5u?S?vq_? N??R??`?Y?o``(nif)0_>e`(ver) 01Y;m`(dil) & ???s?OV?'` ?S?_>ea??A~ ?o?ir?v;??\O(u1\a:_?Eeo?ir????d??g?v???:N gHe:?$?3???$?3??????????????%???????????????????$?3???????????#"PH? QI?Adverse reactions'?6??4Y?0)wUf0YhT4l??vQ-N:Nib _??@??MR@?? ?^???4ltoYu@b? ]x?0Ws^?4Y?0b??0??0??4l?0)wUf0ON?RI{ ??^s|???0)wUf04Y?0YhT4l?0??? 0W\kxSS?4Y?04l?0)wUf0??? N?ex ???????????????????????????????? ?????dRJ?Contraindications'?6??n??^s|00W\kxSS??y(u?N%N??p?0???T?_0II-III?AVB0?'`???? ]x?0Ws^??y(u?NNO@??S?`8 ?????????????????4SK??N Clinical uses & ?@??????? ? ?@??S? t??v?b?@??S\O(u ? ??? (angina pectoris) ?_?W?Oo`??\O ??Q ??c_w? ??? ?o? 3z?[?W??/}0????\O ?? ???^s|00W\kxSS N3z?[?W??f>f?? ?fq_? ?N8^?vQ?\'`tQKY @?Am??Rf[He?^?M?YhT;??R ???M??S ???c???X?R ?b@?\gZ???T?b6R@??s^??????Xu|??((?'????? ??????????,*OXP? Clinical uses'?0??J???:@?????'`:@??T???? ?? N3z?['`????[Nnf?m\T(u ?@??S?{?0-N0???@??S?qSa? 4O??U ?? N?O(u?SO;??o??v?@??S?T????? YhT@???c'`?????? nf?BR?W?]x?0Ws^/???[ ? No???^?u?s???(17-20%)???BR(control-release formunation ??? T)?u?s??x?????? ??????3??????????? X=A YQ? Amlodipine '0 ??yr?? w?Heba ? guir)R(u?? @?o?Sm??7???\?????}Y ???hV_c$O\ ????-N??vNO?u ??f>f?X?RCHF???Q ??@??-NNO?v+T? 2?bkb?l??????S ?? g?bTNF- ?ILI{\O(u zs`ss??????J?????(???r/[S??Nimodipine-<\??< %?'(($ ???yr?? ??@?? ??'`? ?\O(u:_ ??u?@?????Y??f'`?:@??\O0?@?hb_b0?h^X?T?Q?? NT??@?_w??v?@???c0?FT0OP4Y?I{ No???^?v?u?sNOh}J????????F????K\T??J Verapamil-_d?[(isoptin) Diltiazem|& %?'('?(???'?('( %?P  ??XActions ???b6R\O(u??'`???s0?'` O?0?'`???R??'` O?\O(u/f??u5??'`? N??v?@x ?cb?X?R?Q ?@?Am?ib _'Y?v?Q ??T??g ib _@???TM?NO@??S??YhT@?? gf>f?vib _\O(u ??M?NO???vMRT?w? ??^s|?f>f?b6R^?@??s^????v6e);m? ??Y_w???I{ Uses?? N'`??_1Y8^0???0?@??S0??S?W????I{0??^s|??{??c_??^??|??)???(????? ?? ? ???? ???????(????????,|#]U? Other drugs ?0??FCinnarizine and Flunarizine? ??@?? g ??'`? _\O(u ??2?bk:@?:'l@b?^y? _c$O?4N?^(u?N?@???R????x:?@??'`?FT0??O@? ???x?OP4Y??TT?)wUf Perhexiline(?KQf?g)? ;N(u?N3z?['`??? ? No???^:N)wUf0??RI{ Prenylamine(nf<\?f): ??u???0??0??x&?(%?????;???? &?("?(????? &?("?(? ????n  >   ???Questions 1. ?{?????bo??vo?t\O(u?4N?^?^(u0 2. ?{?verapamil0nifedipine 0 nimodipine?v\O(uyr?0 Mx ?$?$?$????(????(?(????$?????$????$???6???R    ? /h     p?   鸢?  ?  c ??? 0??0??p 0 ??  ? ????????藿h? ? f???D???&c??C?r?=?5? eW?4q(??  4 ?  / 0DTimes New Roman4%|dv 0|( 0DArialNew Roman4%|dv 0|( 0g" D?[SOalNew Roman4%|dv 0?胀?.??+,?0L??     屏幕显示  Microsoft t?% 0Times New RomanArial宋体 Wingdings 华文新魏隶书 方正姚体 华文行楷MarlettSymbolSoaring6 钙拮抗药 Calcium channel blockers ?Key points 1. 了解Ca2+的生理学作用; 2. 掌握钙通道阻断药的心、脑血管作用及临床应用; 3. 掌握临床常用的钙拮抗药及其各药的作用特点。}☆ Calcium anatagonist: 是一类阻滞Ca2+ 从细胞外液经电压依赖 性Ca2+通道流入细胞内的药物,又称 Calcium channel blocker 。?第1节 Ca2+ and Ca2+ channels ☆ Ca2+离子的生理意义 ☆ Ca2+通道的类型 ☆ Ca2+通道的分子结构 PowerPoint 演示文稿PowerPoint 演示文稿PowerPoint 演示文稿PowerPoint 演示文稿 ☆ Classifications of the drugs|第2节 Actions and clinical uses pharmacological actions 对心肌的作用 对血管的作用 对其它平滑肌的作用 改善组织血流 其它作用 ☆ 对心肌的作用△ 负性肌力作用 negative inotropic action ⊙ 兴奋-收缩脱偶联,心肌收缩性减弱 ⊙ 心肌耗氧减少 ⊙ 硝苯地平表现为轻微的正性肌力作用 ⊙ 维拉帕米和地尔硫卓负性肌力作用强△ 负性频率和负性传导作用 negative chronotropic and conductive actions ⊙ 窦房结和房室结等慢反应细胞的0相除极和4相缓慢除极都是Ca2+内流所引起 ⊙ Calcium anatagonists : 降低窦房结自律性,心率减慢; 房室结传导速度减慢; 延长有效不应期,消除折返激动.PowerPoint 演示文稿△ 保护缺血心肌作用△ 抗心肌肥厚作用☆ 对血管的作用☆ 对其它平滑肌的作用☆ 改善组织血流的作用5☆ 其它作用 △ 抗动脉粥样硬化: A. 减少细胞内Ca2+离子的超负荷 B. 抑制血小板聚集; C. 抑制 VSMC 增殖、迁移; D. 抑制 c-fos、HMG-CoA 还原酶基因、ECM 基因的表达以及ECM (fibronectin, laminin, 胶原等) 的合成; E. 增加 LDL 受体基因的转录及表达,增加IL-6的产生与分泌——降低胆固醇△ 抑制内分泌: 超过心血管病治疗剂量时 ⊙ 脑垂体后叶:催产素、加压素 ⊙ 脑垂体前叶:ACTH、TSH、促性腺激素 ⊙ 其它:胰岛素、醛固酮 △ 抑制交感神经释放NACa2+拮抗药的作用方式PowerPoint 演示文稿Adverse reactionsContraindications Clinical uses ☆ 心血管系统疾病: △ 高血压: 理想的抗高血压作用 △ 心绞痛 (angina pectoris) 变异型:休息时发作,冠脉痉挛引起,首选药 稳定型:劳累、激动时发作,可选维拉帕米、地尔硫卓 不稳定型:无明显诱因,昼夜都可发作,较严重,维拉帕米和地硫尔卓效果好 △ 心律失常:室上速首选 verapamil; 房颤和房扑。 △ 慢性心功能不全:长效钙拮抗剂,首选 amlodipine △ 肥厚性心肌病:D左心室肥厚(left ventricular hypertrophy, LVH) ⊙ LVH被认为是心血管发病率和病死率升高的重要危险因素 ⊙ LVH产生的严重后果: ? 左室充盈降低 ? 冠脉储备降低 ? 心律失常的发生率及严重程度增加,猝死率增加 ? 左室功能长期进行性降低,终致心衰 ⊙ 钙拮抗剂改善心室顺应性、预防心律失常和使肥厚的心肌缩小。☆ 脑血管疾病:nimodipine、flunarizine等用于脑血管痉挛及血管性头痛 ☆ 其他: 雷诺病—nimodipine、nifedipine 支气管哮喘、食管贲门失弛缓症、急性胃肠痉挛性腹痛、痛经等—verapamil第3节 常用钙拮抗药nifedipine-商品名心痛定Clinical uses AmlodipineNimodipine-尼莫通) Verapamil-异搏定(isoptin) Diltiazem Other drugshQuestions 1. 简述钙拮抗药的药理作用及临床应用。 2. 简述verapamil、nifedipine  D<??,{2?? 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Amlodipine '0 ??yr?? w?Heba ? guir)R(u?? @?o?Sm??7???\?????}Y ???hV_c$O\ ????-N??vNO?u ??f>f?X?RCHF???Q ??@??-NNO?v+T? 2?bkb?l??????S ?? g?bTNF- ?ILI{\O(u zs`ss??????J?????(???r/[S??Nimodipine-<\??< %?'(($ ???yr?? ??@?? ??'`? ?\O(u:_ ??u?@?????Y??f'`?:@??\O0?@?hb_b0?h^X?T?Q?? NT??@?_w??v?@???c0?FT0OP4Y?I{ No???^?v?u?sNOh}J????????F????K\T??J Verapamil-_d?[(isoptin) Diltiazem|& %?'('?(???'?('( %?P  ??XActions ???b6R\O(u??'`???s0?'` O?0?'`???R??'` O?\O(u/f??u5??'`? N??v?@x ?cb?X?R?Q ?@?Am?ib _'Y?v?Q ??T??g ib _@???TM?NO@??S??YhT@?? gf>f?vib _\O(u ??M?NO???vMRT?w? ??^s|?f>f?b6R^?@??s^????v6e);m? ??Y_w???I{ Uses?? N'`??_1Y8^0???0?@??S0??S?W????I{0??^s|??{??c_??^??|??)???(????? ?? ? ???? ???????(????????,|#]U? Other drugs ?0??FCinnarizine and Flunarizine? ??@?? g ??'`? _\O(u ??2?bk:@?:'l@b?^y? _c$O?4N?^(u?N?@???R????x:?@??'`?FT0??O@? ???x?OP4Y??TT?)wUf Perhexiline(?KQf?g)? ;N(u?N3z?['`??? ? No???^:N)wUf0??RI{ Prenylamine(nf<\?f): ??u???0??0??x&?(' ?????;???? &?("?(? ???? &?("?(?  ????n  >   ???Questions 1. ?{?????bo??vo?t\O(u?4N?^?^(u0 2. ?{?verapamil0nifedipine 0 nimodipine?v\O(uyr?0 Mx ?$?$?$????(????(?(????$?????$????$???6???R    ? /h     p?   鸢?  ?  c ??? 0??0??p 0 ??  ? ????????藿h? ? f???D???&c??C?r??=?5? o?G?(??  4 ?  /Root Entry??????????d?O????mC登Pictures????????kuCurrent User????????????:JSummaryInformation(????IP%????????????????????????????????^?]r???????????????     ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHsJKLMNOPQRSTUVWXYZ[???????p_`abcdefghijklm??????q{???tuvwxyz|}~?  !"#$%&'()*+,-./0123456789???;???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????$  $ ob???7?#?g_xO??w?"b?C#3躔K亘?>8???Pw?"b?*W4蜴M???y??w"b?7???p?K?`?&4F"b???x?P?瀑?"l'"b?u彐X5?]? ????I"c ???????1??? f?f33?????33??f@???8??f? u?;?Q6?;g4CdCdv 0p???.???ppp@ <4!d!d` 0,<殁<4dddd` 0,<殁g4&d&dv 0p胡?????p@ pp??___PPT9???>A&T? %?=5??b ????bo? Calcium channel blockers ?2'?<?0?03?'?P3?'?6'?6%????$? ???Key points 1. ?N?Ca2+?vutf[\O(u? 2. ?c????S?;??o??v?0?@??\O(u?4N?^?^(u? 3. ?c?4N?^8^(u?v????bo??vQTo??v\O(uyr?0O} ?6$?$????$N?$?$???$?$???$?$???$;?  ??& Calcium anatagonist? /fN{|;??Ca2+ ???Y??5u?S?OV? '`Ca2+?S?AmeQ???Q?vo?ir ??? Calcium channel blocker 0]?&?0f烃&?0&?6?6?0????$????$????$????$????$???'?$?$???l  ? >6??,{1?? Ca2+ and Ca2+ channels & Ca2+?P[?vutaIN & Ca2+?S??v{|?W & Ca2+?S??vRP[??g j??$#?0?0?0?0?0 ?0'?B&?f烃#?(?$????$????$????(???&?f烃?(????$????$????$????(???&?f烃?(????$????$????$????(???d"?!0HJ? ?7? @8? ? A9? ?B:? C;??<& Classifications of the drugs@'?$f烃%?%??vNLukSu??(WHO)?vR{| N0 ??'`Ca2+??bo? \O(u?NL-?WCa2+?S? 10???{|???^s| verapamil I{ 20?N"l!TvU{|?]x?0Ws^ nifedipine I{ 30?kxSS{|?0W\kxSS Diltiazem ?N0^? ??'`Ca2+??bo? 10?N???{|?Bh)R?0lBh)R?I{ 20nf<\?f{|?nf<\?fI{ 30vQ?[{|??KQf?gI{????????3???????????????3?????? ??????3?????? ????? ??????????????    5D<??,{2?? Actions and clinical uses pharmacological actions ?????v\O(u ?@???v\O(u ?vQ?[s^????v\O(u 9e?U??@?Am vQ?[\O(u [}%?%?%?%??f%?#?0!#? ????? ???,2$? F>??& ?????v\O(u< &?$f烃$?f烃???F?'`???R\O(u ?'`???s?T?'` O?\O(u ??:@????\O(u ?b?????S\O(u$$f?3??$???# ??? ?'`???R\O(u negative inotropic action ?" tQKY-6e)1?vPT? ????6e)'`?1_ ?" ????'l?\ ?" ]x?0Ws^h??:N{???vck'`???R\O(u ?" ??^s|?T0W\kxSS?'`???R\O(u:_Lj?? f烃?????????$??????? ?$????????$????$?$????????$????$?$????$?$???D   8 ? G???H? ?'`???s?T?'` O?\O(u negative chronotropic and conductive actions ?" ??b??T?b??I{ba??^???v0?d??g?T4?bad??g?/fCa2+?QAm@b_w? ?" Calcium anatagonists ? M?NO??b???_'` ???s?ba; ?b?? O????ba; ?? gHe N?^g ??md??b???.?x? f烃?(f烃 ?(,?("?0?????$???? ???? ? ???? ? ???? ? ???? ? ? ???????????'?(??$?$*? ???l  )? H@??IA??? ??:@????\O(u> ? f烃?(f烃 $? ?????:@?:'l???QCa2+???;m??v?0?}vv?0ATPv?I{?????g4xOW?????????TOW{k??????g?T?R?4xOW Ca2+??bo???:g6R? ;??Ca2+?QAm ???6e)?RM?NO ??'l??\ ib _?Q ? ??X?R???@?'l?O? ?b'lS\O(u $9x x, " f?3??????? ????? ????? ????? ? ??? ??  ?? ????? ?? ?? ?? ?? ?? %?? ?f?3r  %JB??? ?b?????S\O(u* ?(f烃$???b6RCa2+?QAm????QCa2+ ??f>f?l????? ?S \O(u:gt? ? _? ? ?M?NOT?w? ?\??N????v?Q?n'`u??P[?v?>e?T/b??b?[??v?u?\O(u(TNF -?TIL)??Y@??'} _ }II0?Q? }-10?Q6?Z??I{#nJn???? ?????????? ??????? ???? ?? ????$$?????? ?????? ?? r: KC??& ?@???v\O(u< &?$f烃&$?(??;N??? _? ? ??Y? ?q_?\?N,? N?X?RY? ??? ? ?Q ??? _'Y?v???@???T\?v;??R@?? ?O?Q ?Am????g????X?R ?@????X?R?@?Am??<\?0Ws^0lBh? ? YhT@????d??c???? ?xEx$????$$????$??? ????? ? ???????? ? ??????? ?? ? ????????\LD??& ?vQ?[s^????v\O(u< &?$f烃$? ?( ?? ~g_/el?s^????2????U???\?? ?>e?TLTD4?vTb ??\?|??vR? ? ??'YBR??~g_?mSS?0?S?0???\? ?P[?s^??????\O(u ?????{|?v\O(u g:_}}}#} ?$$????????????? ?????$$???????? ????,BME??& 9e?U??@?Am?v\O(u> ?$f烃?$ ? ??? ?b6R@?\gZ??? Ca2+?QAm?@?\gZ? ?w????\O(u ?X?R????b_??R ?M?NO@???|? '`?????QCa2+?XY ?vQ?b_??R NM?? ????$?$???$??????? ?????????$ ?$???$??? ?$???$??????? ???? ????F / NF??& vQ?[\O(u ? ?b? ??7hlxS? A. ?\???QCa2+?P[?v???w? B. ?b6R@?\gZ??? C. ?b6R VSMC ?X?k0??? D. ?b6R c-fos0HMG-CoA ??Sv???0ECM ???vh????ECM (fibronectin, laminin, ??SI{) ?vTb? E. ?X?R LDL ?SO???vl?U_?h?? ??X?RIL-6?v?uNR?  M?NO???? x?$f烃?(& ? ?(?$?$? ???? ? ???? ???? ???$???? ???? ?  ? ???? ???? ? ? ???? ???? $? ??? ? ???? ???? ???? ???? ???? #? ???B   ?  ??? ?b6R?QR?? ????@?????uBR?? ?" ??WSOT???? }0?R?S } ?" ??WSOMR??ACTH0TSH0?'`z?? } ?" vQ?[???\ }0???n? ? ?b6R?a^y??>eNAh}? ?(?( ?????$??????? ? ???????????? ??????? ? ???? ?(??? ?(,8 ! nimodipine的作用特点。  已用的字体 演示文稿设计模板 幻灯片标题%%&_?沣sAdministratorsAdministrators? OG??Ca2+??bo??v\O(u?_T &?0.?0&?0??0 ??& ???S??HT N??` & 5u?S?OV?'` 5u?S??'`Ca2+?S??v?R??To?ir?KN\O(u;N???5u?S?vq_? N??R??`?Y?o``(nif)0_>e`(ver) 01Y;m`(dil) & ???s?OV?'` ?S?_>ea??A~ ?o?ir?v;??\O(u1\a:_?Eeo?ir????d??g?v???:N gHe:?$?3???$?3??????????????%???????????????????$?3???????????#"PH? QI?Adverse reactions'?6??4Y?0)wUf0YhT4l??vQ-N:Nib _??@??MR@?? ?^???4ltoYu@b? ]x?0Ws^?4Y?0b??0??0??4l?0)wUf0ON?RI{ ??^s|???0)wUf04Y?0YhT4l?0??? 0W\kxSS?4Y?04l?0)wUf0??? N?ex ???????????????????????????????? ?????dRJ?Contraindications'?6??n??^s|00W\kxSS??y(u?N%N??p?0???T?_0II-III?AVB0?'`???? ]x?0Ws^??y(u?NNO@??S?`8 ?????????????????4SK??N Clinical uses & ?@??????? ? ?@??S? t??v?b?@??S\O(u ? ??? (angina pectoris) ?_?W?Oo`??\O ??Q ??c_w? ??? ?o? 3z?[?W??/}0????\O ?? ???^s|00W\kxSS N3z?[?W??f>f?? ?fq_? ?N8^?vQ?\'`tQKY @?Am??Rf[He?^?M?YhT;??R ???M??S ???c???X?R ?b@?\gZ???T?b6R@??s^??????Xu|??((?'????? ??????????,*OXP? Clinical uses'?0??J???:@?????'`:@??T???? ?? N3z?['`????[Nnf?m\T(u ?@??S?{?0-N0???@??S?qSa? 4O??U ?? N?O(u?SO;??o??v?@??S?T????? YhT@???c'`?????? nf?BR?W?]x?0Ws^/???[ ? No???^?u?s???(17-20%)???BR(control-release formunation ??? T)?u?s??x?????? ??????3??????????? X=A YQ? Amlodipine '0 ??yr?? w?Heba ? guir)R(u?? @?o?Sm??7???\?????}Y ???hV_c$O\ ????-N??vNO?u ??f>f?X?RCHF???Q ??@??-NNO?v+T? 2?bkb?l??????S ?? g?bTNF- ?ILI{\O(u zs`ss??????J?????(???r/[S??Nimodipine-<\??< %?'(($ ???yr?? ??@?? ??'`? ?\O(u:_ ??u?@?????Y??f'`?:@??\O0?@?hb_b0?h^X?T?Q?? NT??@?_w??v?@???c0?FT0OP4Y?I{ No???^?v?u?sNOh}J????????F????K\T??J Verapamil-_d?[(isoptin) Diltiazem|& %?'('?(???'?('( %?P  ??XActions ???b6R\O(u??'`???s0?'` O?0?'`???R??'` O?\O(u/f??u5??'`? N??v?@x ?cb?X?R?Q ?@?Am?ib _'Y?v?Q ??T??g ib _@???TM?NO@??S??YhT@?? gf>f?vib _\O(u ??M?NO???vMRT?w? ??^s|?f>f?b6R^?@??s^????v6e);m? ??Y_w???I{ Uses?? N'`??_1Y8^0???0?@??S0??S?W????I{0??^s|??{??c_??^??|??)???(????? ?? ? ???? ???????(????????,|#]U? Other drugs ?0??FCinnarizine and Flunarizine? ??@?? g ??'`? _\O(u ??2?bk:@?:'l@b?^y? _c$O?4N?^(u?N?@???R????x:?@??'`?FT0??O@? ???x?OP4Y??TT?)wUf Perhexiline(?KQf?g)? ;N(u?N3z?['`??? ? No???^:N)wUf0??RI{ Prenylamine(nf<\?f): ??u???0??0??x&?(%?????;???? &?("?(????? &?("?(? ????n  >   ???Questions 1. ?{?????bo??vo?t\O(u?4N?^?^(u0 2. ?{?verapamil0nifedipine 0 nimodipine?v\O(uyr?0 Mx ?$?$?$????(????(?(????$?????$????$???6???R    ? /h     p?   鸢?  ?  c ??h系??0??p  ??  ? ????????藿h? ? f???D???&c??C?r?=Sr5? _?I