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(?? / 0DArialNew ???鸱0z[ 0"DArial宋体Times New Roman 默认设计模板"Treatment of Parkinson’s diseaseOverview of CNSNeurotransmission in the CNSSynaptic potentialsExcitatory pathwaysInhibitory pathways !Overview of parkinson’s disease 幻灯片 8 Etiology 幻灯片 10 幻灯片 11 etiology( in summary) Strategy of treatmentDrugs used in PDMechanism of action CarbidopaActionsTher_???bweiwei'????alNew ???鸱0z[ 0"D?[SOalNew ???鸱0z[ 0? DTimes New Roman鸱0z[ 0?@ .  @n??" d?d@????  @@``?? 疖?"M     !"#/?R??VAjv 棰`?:??GR?忆i?{???%4??G? ????A???@??蚌?;??;g4[d[d z[ 0???????ppp@ <4ddddL 0??? ??___PPT10??D?[SOes New ??し?0しz[ 0??DTimes New Romanし?0しz[ 0? pp???@Treatment of Parkinson s disease? ?Overview of CNS?Act presynaptically by influencing the production, storage, or termination of action of neurotransmitters. 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Inhibitory postsynaptic potentials (IPSP) are 1. releases neurons releases neurotransmitter molecules, such as -aminobutyric acid (GABA) or glycine. Increase in the permeability of specific ions, such as, potassium and chloride ions 2. the influx of chloride and efflux of potassium cause a weak hyperpolarization or IPSP that moves the postsynaptic potential away from its firing threshold. 8lcoA"t ? ?O ??>Overview of parkinson s disease  ??Parkinson's disease (PD) is a progressive disorder of the nervous system. With an annual incidence of approximately 20 new cases per 100,000 people. PD is generally age-specific; it is estimated that approximately 1% of the population over age 60 has PD. ?  ?Etiology?~Is correlated with a reduction in the activity of inhibitory dopaminergic neurons in the substantia nigra and corpus striatum.>=      ??Substantia nigra striatum Fire tonically, rather than in response to specific muscular movements or sensory input. GABA dopamine >?6  x ? etiology( in summary) ??Destruction of cells in the substantia nigra results in the degeneration of neurons responsible for secreting dopamine in the neostriatum.> R  ?Strategy of treatment?zTherapy is aimed at restoring dopamine in the basal ganglia and antogonizing the excitatory effect of cholinergic neurons.@ / ?Drugs used in PD? levodopa(L-dopa) and carbidopa $ ?Mechanism of action?Levodopa: replenish the dopamine deficiency. Dopamine itself does not cross the blood-brain barrier. Levodopa is readily transported into the CNS and is coverted to dopamine in the brain. But side effects in the periphery.6_,>? Carbidopa ??A dopamine decarboxylase inhibitor that does not cross the blood-brain barrier Diminishes the metabolism of levodopa in the GI tract and peripheral tissues, T(?Actions?CLevodopa decreases the rigidity, tremors, and other symptoms of PD <?Therapeutic uses?BLevodopa in combination with carbidopa is a potent and efficacious$ ?Absorption and metabolism?oLevodopa has extremely short half-life(1 to 2 hours) Taken on an empty stomach, typically 45 min before a meal.h?Adverse effects?@Peripheral effects: anorexia, nausea, and vomitting Hypotension* ? CNS effects?HVisual and auditory hallucinations and dyskinesia Depression and anxiety' ? Interactions ?jThe vitamin pyridoxine(V6) increases the peripheral breakdown of levodopa and diminishes its effectiveness&k??A"? Bromocriptine ?`Is a dopamine receptor agonist Produces little response in patients who do not react to levodopaX $ ? ??`P??  P? P S ??? `}   ?? P S ?h_? `  ?? 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Current User????????????)SummaryInformation(?????PowerPoint Document(????????????~??DocumentSummaryInformation8?????????????????????????????????[SOalNew ???鸱0z[ 0? DTimes New Roman鸱0z[ 0?@ .  @n??" d?d@????  @@``?? t?皎L)     /?R??VAjv 棰`?:??GR?忆i?{???%4??G? ????A???@??蚌?;??;g4[d[d z[ 0???????ppp@ <4ddddL 0??? ??___PPT10??D?[SOes New ??し?0しz[ 0??DTimes New Romanし?0しz[ 0? ppW??@Treatment of Parkinson s disease? ?Overview of CNS?Act presynaptically by influencing the production, storage, or termination of action of neurotransmitters. Other agents may activate or block postsynaptic receptor.??Neurotransmission in the CNS?Similar to autonomic nervous system The circuitry of the CNS is much more complex than the autonomic nervous system Contains powerful networks of inhibitory neurons that are constantly active More than 10 neurotransmitters&t???Synaptic potentials?Receptors at most synapses are coupled to ion channels. Depolarization or hyperpolarization of the postsynaptic membrane, depending on the specific ions that move and the direction&<??JZ?Excitatory pathways?%Excitatory postsynaptic potential(EPSP) are generated by the following 1. stimulation of an excitatory neuron causes the release of neurotransmitter molecules 2. The influx of Na+ causes a weak depolarization 3. Pass a threshold, and an all-or-none action potential is generated. "HZZ&?Inhibitory pathways ???Results in a hyperpolarization of the postsynaptic membrane. Inhibitory postsynaptic potentials (IPSP) are 1. releases neurons releases neurotransmitter molecules, such as -aminobutyric acid (GABA) or glycine. Increase in the permeability of specific ions, such as, potassium and chloride ions 2. the influx of chloride and efflux of potassium cause a weak hyperpolarization or IPSP that moves the postsynaptic potential away from its firing threshold. 8lcoA"t ? ?O ??>Overview of parkinson s disease  ??Parkinson's disease (PD) is a progressive disorder of the nervous system. With an annual incidence of approximately 20 new cases per 100,000 people. PD is generally age-specific; it is estimated that approximately 1% of the population over age 60 has PD. ?  ?Etiology?~Is correlated with a reduction in the activity of inhibitory dopaminergic neurons in the substantia nigra and corpus striatum.>=      ??Substantia nigra striatum Fire tonically, rather than in response to specific muscular movements or sensory input. GABA dopamine >?6  x2 ? ?@H??  H? H S ?H?? `}  ? ?? H S ?斜?? ` ? ??B H s ?D? ~ ?B H s ?D?V * V ?B H@ s ?D? *] ? 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Current User????????????8SummaryInformation(?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? ??? ???!"#???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????Arial宋体Times New Roman 默认设计模板"Treatment of Parkinson’s diseaseOverview of CNSNeurotransmission in the CNSSynaptic potentialsExcitatory pathwaysInhibitory pathways !Overview of parkinson’s disease 幻灯片 8 Etiology 幻灯片 10 幻灯片 11 etiology( in summary) Strategy of treatmentDrugs used in PDMechanism of action CarbidopaActionsTher _???微软用户?o?(u7b?